Sphingosine kinase 1 regulates inflammation and contributes to acute lung injury in pneumococcal pneumonia via the sphingosine-1-phosphate receptor 2
B Gutbier, SM Schönrock, C Ehrler… - Critical care …, 2018 - journals.lww.com
Objectives: Severe pneumonia may evoke acute lung injury, and sphingosine-1-phosphate
is involved in the regulation of vascular permeability and immune responses. However, the
role of sphingosine-1-phosphate and the sphingosine-1-phosphate producing sphingosine
kinase 1 in pneumonia remains elusive. We examined the role of the sphingosine-1-
phosphate system in regulating pulmonary vascular barrier function in bacterial pneumonia.
Design: Controlled, in vitro, ex vivo, and in vivo laboratory study. Subjects: Female wild-type …
is involved in the regulation of vascular permeability and immune responses. However, the
role of sphingosine-1-phosphate and the sphingosine-1-phosphate producing sphingosine
kinase 1 in pneumonia remains elusive. We examined the role of the sphingosine-1-
phosphate system in regulating pulmonary vascular barrier function in bacterial pneumonia.
Design: Controlled, in vitro, ex vivo, and in vivo laboratory study. Subjects: Female wild-type …
